Melva and her husband Ervin (Skip) are the founding pastors of World Outreach & Bible Training Center located in Glendale, Wisconsin. She is also the President of Melva Henderson Ministries, an outreach which affords her the privilege of serving others, traveling nationally and internationally as humanitarian, minister, and itinerant teacher. Melva is the founder of several charitable outreaches including: The Milwaukee Give, an annual outreach which feeds and clothes thousands in order to alleviate the effects of poverty for those within the inner city of Milwaukee, Wisconsin; and The Little Feet of Mexico, an international effort launched in 2008 providing new and gently used shoes and clothes to children in remote villages of Mexico.

Melva is the founder of World Bible Training Institute, a school that trains and develops individuals for full ­time ministry careers. She is the State Director for Daughters for Zion, a prayer ministry under Christians United for Israel (CUFI). Melva is also the host of  Discipling the Nations  global radio and television broadcasts aired weekly on the Trinity Broadcasting Network (TBN) and a featured guest on several Christian television shows including The Believer’s Voice of Victory Broadcast with Kenneth and Gloria Copeland. She is a 1992 graduate of Rhema Bible Training Center and author of the highly sought after daily devotional Fresh Baked Manna.